Contents

Chapter 1
Anatomy of the
immune system

Chapter 2
Important molecules

Chapter 3
The development of
the immune system

Chapter 4
The physiology of
the immune response

Chapter 5
Immunity to infections

Chapter 6
Pathological reactions
of the immune system

Chapter 7
The immune defence against tumours

Chapter 8
Transplantations

Chapter 9
Immunological methods

4.1. Innate immunity

4.2. The induction of the adaptive immune response

        4.2.1. Antigen presentation
                    - The discovery of MHC-restriction
                    - The structure of T cell peptide epitopes

        4.2.2. T cell activation
                    - Counting antigen-specific T cells using Tetrameric peptide-MHC-complexes    
                    - The immunological synapse (SMACS)
                    - Measuring cell proliferation
                            - CFSE

        4.2.3. B cell activation
                    - B cell memory
                    - The germinal centre reaction
                            - Somatic hypermutation - where does it happen
                            - AID, an enzyme essential for class switching and somatic hypermutation

4.3. Immune effector mechanisms and their regulation

        4.3.1. The humoral immune response

        4.3.2. The cellular immune response
                    - Apoptosis
                            - DNA ladder
                            - TUNEL reaction

        4.3.3. Immunotolerance

4.4. Memory