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B cell memory | |
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What was known before? There is evidence that B cell memory, which is mediated by antibodies, can be effective for many years. This memory is carried by memory B cells that recognize antigen by high-affinity antibodies. They develop in response to an antigen challenge with the help of T cells. The memory B cell population can be very long lived. The important questions A lot of research was focussed on the mechanism of the long-term survival of memory B cells. However, it was impossible to clarify whether an ongoing immune response triggered by minute amounts of residual antigen is necessary for the persistence of B cell memory. The problem is that it is impossible to be completely sure that all antigen has been removed from an organism after immunization. The experiment  B cell response The molecular view The experimentRelated paper Maruyama M, Lam KP, Rajewsky K. 2000 Oct 5. Memory B-cell persistence is independent of persisting immunizing antigen. Nature. 407(6804):636-42. Erratum in: Nature 2001 Jan 18;409(6818):382. Related topic  The Cre-lox system |
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