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The genetic basis of tumour specific tumour antigens | |
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What was known before? Tumour cells usually grow in syngeneic mice and cause tumours. Some tumour cell variants, however, express new tumour specific antigens that are recognized by syngeneic cytotoxic T cells. They are no more tumourigenic. Such variants are called tum negative (tum-). Due to the lack of specific antibodies, the structure of these tumour specific antigens was not known at the time. Therefore, Boon and his team decided to use a genetic approach. They wanted to directly identify the genes encoding the tumour antigens in tum- tumour cell variants. The important questions What is the genetic origin of tum- antigens? What is their structure? The experiment  Related paper Sibille C, Chomez P, Wildmann C, Van Pel A, De Plaen E, Maryanski JL, de Bergeyck V, Boon T. 1990. Structure of The Gene of tum- Transplantation Antigen P198 : A Point Mutation Generates a New Antigenic Peptide. J Exp Med 172: 35-45 |
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