Spontaneously diabetic Chinese hamsters (Cricetulus griseus)
Two sublines were derived from the Central Institute of Laboratory Animal Breeding, Hannover in 1990, CHIA/Han and CHIG/Han. Both subline were phenotypically characterized and bred since that time in Karlsburg.
Some characteristics of CHIA/Han and CHIG/Han hamsters
|
CHIA/Han |
CHIG/Han |
|||
|
nondiabetic |
nondiabetic |
diabetic |
diabetic |
|
|
severe |
mild |
|||
| No. of animals |
65 |
25 |
74 |
38 |
| Age at onset (weeks) |
11 ± 5 |
23 ± 10 |
||
| Plasma glucose (mg / %) |
96 ± 16 |
110 ± 27 |
226 ± 110 |
407 ± 123 |
| Plasma insulin (pmol / l) |
337 ± 242 |
792 ± 523 |
691 ± 531 |
263 ± 261 |
| Triglycerides (mmol / l) |
5.6 ± 2.0 |
6.6 ± 2.7 |
8.2 ± 3.7 |
7.1 ± 3.4 |
| Cholesterol (mmol / l) |
2.9 ± 0.6 |
3.2 ± 1.0 |
3.3 ± 1.0 |
3.5 ± 0.7 |
| Urine creatinine (mmol / l) |
2.0 ± 1.1 |
3.5 ± 1.6 |
2.9 ± 1.7 |
1.3 ± 1.2 |
| Urine urea (mol / l) |
0.6 ± 0.3 |
1.0 ± 0.4 |
0.8 ± 0.4 |
0.4 ± 0.3 |
More details:
Klöting, I., Sickel, E., Vogt, L., Kohnert, K.D. & K.G. Rapp. 1993. Das spontandiabetische CHIG/Han-Hamster Modell für die Diabetologie. Dtsch.tierärztl.Wschr. 100, 417-18.
Klöting, I., Sickel, E., Vogt, L. & K.D. Kohnert. 1994. CHIG/Han hamsters: an animal model for diabetes research.Welfare and Science, FELASA Proceedings, Royal Society of Medicine Press, London 1994, 190-194.
Kohnert, K.D., Hehmke, B., Besch, W., Keßler, J. & I. Klöting. 1995. Impaired ß-cell function in the Chinese hamster CHIG/Han subline. Exp. Clin. Endocrinol. 103: 66-70.
Bettin, D., Klöting, I. & K.D. Kohnert. 1996. Alterations in erythrocyte plasma membrane ATPase activity and adenine nucleotide content in spontaneously diabetic subline of Chinese hamster. Horm. Metab. Res. 28: 1-6.
S. Tetzlaff. 1996. Phänotypische Charakterisierung von CHIG/Han- and CHIA/Han-Hamstern zwecks Beurteilung ihrer Eignung als Modell in der experimentellen Diabetologie, Diss., Medizinische Fakultät, Univ. Greifswald