Structural and mechanistic studies on the dynamin GTPase

Dynamin is a mechano-chemical GTPase that oligomerizes at the neck of clathrin-coated vesicles and catalyzes vesicle scission in a GTP hydrolysis dependent fashion. Here, I discuss our structural analyses on various dynamin superfamily members, which clarifies the mode of assembly and its membrane-dependent activation. Using a combination of biochemical and computational approaches, I present a mechanistic model for the action of dynamin at the vesicle neck.

Einladender: Prof. Dr. Michael Lammers
PD Dr. Heike Kahlert, Vorsitzende des Ortsverbandes der GDCh

Ansprechpartner
Institut für Biochemie
Verwaltung
Felix-Hausdorff-Straße 4, 17489 Greifswald
Telefon 03834 420 4304
balzer(at)uni-greifswald(dot)de

 

 

Organisator

  • Institut für Biochemie

Veranstaltungsort

  • Biochemie, Großer Hörsaal

    Institut für Biochemie, Felix-Hausdorff-Straße 4
    17489 Greifswald


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