The lecture will discuss peculiarities of the synthesis, spectral properties, and potential biomedical applications of alfa-aryl substituted metal phthalocyanines recently developed in our group. Phthalocyanines are very common dyes which find a diverse use in every days life. Our Synthetic team at Tampere University specializes in the development of functional photoactive molecules, and recently we have prepared a phthalocyanine photosensitizer LASU having unusually strong photoantimicrobial efficiency.
The molecule was well suitable for dyeing textiles and allowed to prepare reusable self-disinfecting fabrics with strong antibacterial and anti-COVID action. The textiles showed a significant photodynamic effect even under moderate indoor light, which made them suitable for general use, e.g. in households and public places. Developing further the possible application area of a powerful and stable photosensitizer, we impregnated the LASU phthalocyanine into a nanofiber cellulose hydrogel, which allowed us releasing a cargo drug from the hydrogel-encapsulated liposomes under light triggering.
By making the phthalocyanine’s periphery hydrophobic and by tuning the regioisomeric patterns, we were also able to incorporate the photosensitizers directly into the liposomal membranes and to obtain an efficient release of the cargo molecules upon far-red excitation.
Kontakt zum Veranstalter
Institut für Biochemie
Felix-Hausdoff-Straße 4, 17489 Greifswald
Telefon +49 3834 420 4304
Balzeruni-greifswaldde